| | Photodynamic therapy (PDT) requires three components for success, a photosensitiser, light and molecular oxygen. All three components are necessary if the PDT effect is to occur and the aim of successful PDT is to ensure adequate amounts of each in the target tissue. [more...] | |
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| | Topical 5-aminolaevulinic acid (ALA) photodynamic therapy (PDT) is used increasingly for superficial
non-melanoma skin cancer (NMSC) and dysplasia. However, the relative accumulation of the photosensitizer protoporphyrin IX (PpIX) in diseased tissue is not specific for neoplastic disease ...[more...] | |
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| | | The topical application of δ-aminolevulinic acid (ALA) induces porphyrin formation in the skin, preferentially in tumor tissues. Irradiation of the porphyrin-enriched tumor tissue with Wood’s light leads to emission of a brick-red fluorescence. This principle may be used as a diagnostic procedure which may be...[more...] | |
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| | | Topical photodynamic therapy (PDT) is effective in the treatment of certain non-melanoma skin cancers and is under evaluation in other dermatoses. Its development has been enhanced by a low rate of adverse events and good cosmesis. 5-Aminolaevulinic acid (ALA) is the main agent used...[more...] | |
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| | | Topical aminolaevulinic acid-based photodynamic therapy (ALA-PDT) has recently been tried in small open studies for several inflammatory dermatoses including psoriasis...[more...] | |
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| | | Propionibacterium acnes is a Gram-positive, microaerophilic bacterium that causes skin wounds. It is known to naturally produce high amounts of intracellular porphyrins. The results of the present study confirm that the investigated strain of P. acnes is capable of producing endogenic porphyrins with no need for any trigger ...[more...] | |
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